Benign, Multicentric, Recurrent and Metastasizing Giant Cell Tumor of Bone: Review of Literature with Role of Immunohistochemistry in Determining Prognosis Authors

1 M.D. Pathology, Assistant Professor, Depat of Pathology, J.N.Medical College, A.M.U, Aligarh, UP, India Email: [email protected] 2 Junior Resident, Department of Pathology, J.N. Medical College, A.M.U, Aligarh, UP, India 202001 Email: [email protected] 3 M.D. Pathology, Professor, Dept of Pathology, J.N.Medical College, A.M.U., Aligarh, UP, India 202001 Email: [email protected] 4 Junior Resident, Department of Pathology, J.N.Medical College, A.M.U., Aligarh, U.P., India 202001 Email: [email protected] 5 Junior Resident, Department of Pathology, J.N.Medical College, A.M.U., Aligarh, U.P., India 202001 Email: [email protected] 5 MBBS, D. Orthopaedics, J.N.Medical College, A.M.U., Aligarh, U.P., India 202001 Email: [email protected] Corresponding Author Dr. Divya Rabindranath Department of Pathology, J.N.Medical College, A.M.U., Aligarh, U.P., India 202001 Email: [email protected]. Ph:+917895683197 Abstract: Objective: Giant cell tumor (GCT) represents around 4-5% of all primary bone tumors. The purpose of this article is to report this unusual case of benign metastasizing GCT and simultaneously emphasize on the role of immunomarkers in predicting the aggressive behaviour of such lesions and a brief review of literature along with the proposed management strategies in these patients. Case: We report a rare case of benign GCT in a 24 years old Asian female. Initial presentation of the disease was 9 years back with involvement of lower end of right humerus; development of a multicentric lesion in right 4 th